Interleukin-35 as an Emerging Player in Tumor Microenvironment

Xue, Wenhua; Yan, Dan; Kan, Quancheng

Immune cells consist of multiple checkpoints where distinct types of immune cell(s) are responsible for any unwarranted entry. Like security blankets, immune system cells work in number of layers with each layer responsible for sustainability of respective microenvironment and destruction of unwanted endogenous and exogenous substances [41] . Hence functions of immune system cells is not restricted to killing the foreign substances brazenly, but also to evaluate the antigens, recognize and establish the self tolerance, maintain homeostatic conditions and even regulate the functions of other tissues. Such large scale intelligent modulation by immune system is largely exercised through its regulatory wings namely Tregs and Breg cells [42] [43] [44] [45] .