Author: Linder, Kathleen A; McDonald, Philip J; Kauffman, Carol A; Revankar, Sanjay G; Chandrasekar, Pranatharthi H; Miceli, Marisa H
Title: Infectious Complications After Umbilical Cord Blood Transplantation for Hematological Malignancy Document date: 2019_2_22
ID: qu20hqch_1
Snippet: Umbilical cord blood (UCB) cells are a suitable source of stem cells for patients who require hematopoietic cell transplantation (HCT) and who do not have a matched donor [1] . The use of UCB cells has been mostly studied in children with hematological malignancies, but it has extended to the adult population because of the paucity of related or matched donors [1, 2] . Advantages to using UCB cells for HCT include the ability to use human leukocy.....
Document: Umbilical cord blood (UCB) cells are a suitable source of stem cells for patients who require hematopoietic cell transplantation (HCT) and who do not have a matched donor [1] . The use of UCB cells has been mostly studied in children with hematological malignancies, but it has extended to the adult population because of the paucity of related or matched donors [1, 2] . Advantages to using UCB cells for HCT include the ability to use human leukocyte antigen (HLA)-mismatched cells without significant adverse effects on graft function and the decreased incidence of graft-versus-host disease (GVHD) after transplantation [1, 3] . However, both the decreased quantity of cells available for transplantation and the immunological immaturity of UCB cells have been linked to delayed engraftment after UCB transplant (UCBT) [3, 4] .
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