Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_36
Snippet: The concept of macrophage polarization was first defined in 1992, almost 80 years after Metchnikoff's initial description of macrophage activation [1, 7] . The alternatively activated macrophages secrete anti-inflammatory mediators, promote tissue repair, and regulate immune response in the initiation, development, and cessation of many inflammatory diseases through signal pathways including STATs, interferon regulatory factors (IRFs), NF-κB, AP.....
Document: The concept of macrophage polarization was first defined in 1992, almost 80 years after Metchnikoff's initial description of macrophage activation [1, 7] . The alternatively activated macrophages secrete anti-inflammatory mediators, promote tissue repair, and regulate immune response in the initiation, development, and cessation of many inflammatory diseases through signal pathways including STATs, interferon regulatory factors (IRFs), NF-κB, AP1, PPARγ and CREB [12] . The important areas for future work should focus on exploring the full spectrum of macrophage polarization, uncovering the mechanisms with regard to the transformation of polarization, and finding the targets to the therapies of inflammatory diseases [22] .
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