Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_27
Snippet: The extracellular domain of SLAM associates with another SLAM molecule present on adjacent cells. In CD4 + T-cells, ligation of SLAM induces its binding to SAP, and combined with T-cellreceptor (TCR)-mediated signals, triggers downstream signaling for the production of T helper 2 (Th2) cytokines such as IL-4 and IL-13 (Veillette et al., 2007) . Furthermore, SLAM controls production of IL-12, tumor necrosis factor α, and nitric oxide, presumably .....
Document: The extracellular domain of SLAM associates with another SLAM molecule present on adjacent cells. In CD4 + T-cells, ligation of SLAM induces its binding to SAP, and combined with T-cellreceptor (TCR)-mediated signals, triggers downstream signaling for the production of T helper 2 (Th2) cytokines such as IL-4 and IL-13 (Veillette et al., 2007) . Furthermore, SLAM controls production of IL-12, tumor necrosis factor α, and nitric oxide, presumably via EAT-2, by macrophages (Veillette et al., 2007) .
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