Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_31
Snippet: To identify the host cells that support infection, a recombinant CDV that expressed green fluorescent protein (GFP) was produced by reverse genetics, based on a wild-type strain that is lethal to ferrets, and inoculated intranasally into animals (von Messling et al., 2004) . CDV initially infected lymphocytes and massively replicated therein, thereby causing immunosuppression, systemic invasion, and host escape. In contrast, replication in epithe.....
Document: To identify the host cells that support infection, a recombinant CDV that expressed green fluorescent protein (GFP) was produced by reverse genetics, based on a wild-type strain that is lethal to ferrets, and inoculated intranasally into animals (von Messling et al., 2004) . CDV initially infected lymphocytes and massively replicated therein, thereby causing immunosuppression, systemic invasion, and host escape. In contrast, replication in epithelial cells was initially not detectable but substantial before host death.
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