Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_45
Snippet: The nectin family is a cell adhesion molecule family comprising four members (nectin-1-4), and only nectin-4 functions as the EpR (Mühlebach et al., 2011; Noyce et al., 2011) . Nectins contain immunoglobulin-like domains, similar to SLAM. The nectin family proteins have recently been shown to be essential contributors to the formation of cell-cell adhesions and are novel regulators of cellular activities, including cell polarization, differentia.....
Document: The nectin family is a cell adhesion molecule family comprising four members (nectin-1-4), and only nectin-4 functions as the EpR (Mühlebach et al., 2011; Noyce et al., 2011) . Nectins contain immunoglobulin-like domains, similar to SLAM. The nectin family proteins have recently been shown to be essential contributors to the formation of cell-cell adhesions and are novel regulators of cellular activities, including cell polarization, differentiation, movement, proliferation, and survival (Takai et al., 2008; Ogita et al., 2010) . Nectins are also involved in the establishment of apical-basal polarity at cell-cell adhesion sites and the formation of tight junctions in epithelial cells (Takai et al., 2008; Ogita et al., 2010) .
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