Author: Gunn, Michael D.; Kyuwa, Shigeru; Tam, Carmen; Kakiuchi, Terutaka; Matsuzawa, Akio; Williams, Lewis T.; Nakano, Hideki
Title: Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization Document date: 1999_2_1
ID: sz28ar3t_28
Snippet: Because SLC is expressed in lymphatic endothelium, we examined the possibility that the defect in DC migration from skin to LNs in plt mice is due to an inability of activated DCs to enter afferent lymphatics. Our findings argue against this possibility, as DCs in skin cultured from plt mice were able to migrate normally out of the epidermis, collect in lymphatics, and move out of the skin in normal numbers (Fig. 6 ). Although these results do no.....
Document: Because SLC is expressed in lymphatic endothelium, we examined the possibility that the defect in DC migration from skin to LNs in plt mice is due to an inability of activated DCs to enter afferent lymphatics. Our findings argue against this possibility, as DCs in skin cultured from plt mice were able to migrate normally out of the epidermis, collect in lymphatics, and move out of the skin in normal numbers (Fig. 6 ). Although these results do not rule out the existence of a subtle defect in the mobilization of peripheral DCs, they suggest that the DC homing defect in plt mice occurs at the level of DC entry into T cell zones. At present, the function of SLC in lymphatic endothelium remains unknown.
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