Author: Nicola Clementi; Elena Criscuolo; Roberta Antonia Diotti; Roberto Ferrarese; Matteo Castelli; Roberto Burioni; Massimo Clementi; Nicasio Mancini
Title: Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro Document date: 2020_3_31
ID: fhy2z49t_20
Snippet: Cell supernatants of different experimental settings were collected and analyzed by RT-PCR, and results confirmed CPE data analysis (Fig. 3) . In detail, a significant statistical difference of Delta Ct was observed with HCQ full-time treatment compared to infection control, both at 37°C (P < 0.05) and 4°C (P < 0.0001) virus adsorption, while HCQ post-adsorption treatment was effective (P < 0.0001) only when the virus was added to cells at 4°C.....
Document: Cell supernatants of different experimental settings were collected and analyzed by RT-PCR, and results confirmed CPE data analysis (Fig. 3) . In detail, a significant statistical difference of Delta Ct was observed with HCQ full-time treatment compared to infection control, both at 37°C (P < 0.05) and 4°C (P < 0.0001) virus adsorption, while HCQ post-adsorption treatment was effective (P < 0.0001) only when the virus was added to cells at 4°C. Interestingly, BFLA addition to HCQ pre-adsorption treatment resulted in a significant statistical difference of Delta Ct when compared to infection control at 37°C virus adsorption. author/funder. All rights reserved. No reuse allowed without permission.
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