Selected article for: "antiviral activity and SARS antiviral activity"
Author: Nicola Clementi; Elena Criscuolo; Roberta Antonia Diotti; Roberto Ferrarese; Matteo Castelli; Roberto Burioni; Massimo Clementi; Nicasio Mancini
Title: Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro
  • Document date: 2020_3_31
    • ID: fhy2z49t_24
    Snippet: In the prophylactic setting (pre-adsorption), 10uM HCQ did not interfere effectively with the viral replicative cycle neither at 37°C nor at 4°C, as evidenced in the CPE and the RT-PCR analysis. A limited antiviral activity was also observed in the therapeutic setting (postadsorption) but, interestingly, a higher HCQ antiviral activity was observed at 4°C, suggesting its predominant SARS-CoV-2 interference at the endosomal level 10, 11 . Overa.....
    Document: In the prophylactic setting (pre-adsorption), 10uM HCQ did not interfere effectively with the viral replicative cycle neither at 37°C nor at 4°C, as evidenced in the CPE and the RT-PCR analysis. A limited antiviral activity was also observed in the therapeutic setting (postadsorption) but, interestingly, a higher HCQ antiviral activity was observed at 4°C, suggesting its predominant SARS-CoV-2 interference at the endosomal level 10, 11 . Overall, and most importantly, these results suggest a limited activity of HCQ when administered only prophylactically or therapeutically.

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