Author: Morgan, Brittany S; Forte, Jordan E; Hargrove, Amanda E
Title: Insights into the development of chemical probes for RNA Document date: 2018_9_19
ID: wupre5uj_3
Snippet: While ligands that bind non-ribosomal RNA in vitro have been reported for decades, the development of chemical probes with evidence of specific small molecule:RNA engagement in cell or animal models has dramatically increased in the last four years. Recent studies report several drug-like small molecules that target a range of RNAs in animal models, including riboswitches (15) , miRNAs, (16, 17) splice sites (18) , and mature mRNAs (19) , at leas.....
Document: While ligands that bind non-ribosomal RNA in vitro have been reported for decades, the development of chemical probes with evidence of specific small molecule:RNA engagement in cell or animal models has dramatically increased in the last four years. Recent studies report several drug-like small molecules that target a range of RNAs in animal models, including riboswitches (15) , miRNAs, (16, 17) splice sites (18) , and mature mRNAs (19) , at least one of which is currently in clinical trials (NCT02268552). Multivalent ligands have been reported that target r(CUG) exp repeats of Myotonic Dystrophy Type 1 (DM1) in D. melanogaster (20) and mouse models (21) . These recent successes confirm that selective RNA targeting is achievable in biological systems; however, the limited examples over years of effort highlight the challenges associated with selectively probing RNA.
Search related documents:
Co phrase search for related documents- animal cell and clinical trial: 1, 2, 3, 4, 5, 6
- animal cell and mouse model: 1, 2, 3, 4, 5, 6, 7, 8
- animal cell and recent study: 1, 2
- animal cell model and mouse model: 1, 2, 3
- animal model and biological system: 1
- animal model and clinical trial: 1, 2, 3, 4, 5, 6, 7, 8, 9
- animal model and mouse model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and recent study: 1, 2, 3, 4, 5, 6, 7
- biological system and chemical probe: 1, 2
- biological system and clinical trial: 1, 2, 3, 4
- biological system and mouse model: 1, 2
- clinical trial and effort highlight: 1
- clinical trial and mouse model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- clinical trial and recent study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- mouse model and recent study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date