Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress Document date: 2017_2_28
ID: w731ehtz_1
Snippet: Cells continuously encounter a wide variety of intrinsic and extrinsic stresses that damage the integrity of DNA (Lindahl and Barnes, 2000) . Mitochondrial respiratory chain generates reactive oxygen species (ROS), which are the most prevalent intrinsic source of DNA damage. Extrinsic sources of DNA damage are ionizing radiation (IR), ultraviolet (UV), and genotoxic chemical agents, including chemotherapeutic drugs (e.g., camptothecin, doxorubici.....
Document: Cells continuously encounter a wide variety of intrinsic and extrinsic stresses that damage the integrity of DNA (Lindahl and Barnes, 2000) . Mitochondrial respiratory chain generates reactive oxygen species (ROS), which are the most prevalent intrinsic source of DNA damage. Extrinsic sources of DNA damage are ionizing radiation (IR), ultraviolet (UV), and genotoxic chemical agents, including chemotherapeutic drugs (e.g., camptothecin, doxorubicin, and etoposide). Both of the sources attack DNA and produce DNA lesions or breaks (Dipple, 1995) . If not properly repaired, these damages are capable of blocking DNA replication and transcription, leading to mutations or genome aberrations, which consequently give rise to various human diseases, such as cancer.
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