Selected article for: "DDR dna damage response and dna damage response"
Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress
  • Document date: 2017_2_28
    • ID: w731ehtz_2
    Snippet: To maintain genome stability against the stresses, cells operate DNA damage response (DDR) to detect DNA lesions, signal their presence, and promote their repair (Harrison and Haber, 2006; Harper and Elledge, 2007; Rouse and Jackson, 2002) . If DDR alone cannot completely handle DNA damage, cells employ an additional defense mechanism, called DNA damage tolerance (DDT) that allows DNA replication with the bypass of DNA lesions, which eventually i.....
    Document: To maintain genome stability against the stresses, cells operate DNA damage response (DDR) to detect DNA lesions, signal their presence, and promote their repair (Harrison and Haber, 2006; Harper and Elledge, 2007; Rouse and Jackson, 2002) . If DDR alone cannot completely handle DNA damage, cells employ an additional defense mechanism, called DNA damage tolerance (DDT) that allows DNA replication with the bypass of DNA lesions, which eventually is repaired at a later stage . Both DDR and DDT are tightly controlled by post-translational protein modifications (PTMs), including phosphorylation, acetylation, methylation, poly (ADP-ribosyl)ation, and modification by ubiquitin and ubiquitin-like proteins (UBLs). Ubiquitin and UBLs are henceforth referred to as the ubiquitin family. When cells are seriously damaged by genotoxic stresses and cannot be repaired by DDR and DDT, they are then committed to kill themselves through a suicide process, called apoptosis. PTMs are also critically involved in the control of apoptotic process for selective and permanent elimination of damaged cells.

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