Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress Document date: 2017_2_28
ID: w731ehtz_22
Snippet: Notably, cisplatin, unlike camptothecin and doxorubicin, is unable to induce the ISG15-congugating system and ï„Np63ï¡ ISGylation, although it also acts as a DNA-damaging agent as well as an anticancer drug. However, cisplatin is capable of inducing cAbl-mediated phosphorylation of TAp73, which causes the dissociation of TAp73 from ï„Np63ï¡ and in turn the promotion of its transcriptional activity to induce apoptosis (Leong et al., 2007) . Th.....
Document: Notably, cisplatin, unlike camptothecin and doxorubicin, is unable to induce the ISG15-congugating system and ï„Np63ï¡ ISGylation, although it also acts as a DNA-damaging agent as well as an anticancer drug. However, cisplatin is capable of inducing cAbl-mediated phosphorylation of TAp73, which causes the dissociation of TAp73 from ï„Np63ï¡ and in turn the promotion of its transcriptional activity to induce apoptosis (Leong et al., 2007) . Thus, cisplatin, like camptothecin and doxorubicin, impairs the dominant-negative function of ï„Np63ï¡ toward TA domain-containing p53 family members, although it does not exhibit any effect on ISGylation and caspase-2-mediated cleavage of ï„Np63ï¡, unlike camptothecin and doxorubicin.
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