Author: Ma, J; Wan, J; Meng, J; Banerjee, S; Ramakrishnan, S; Roy, S
Title: Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor Document date: 2014_3_6
ID: wu2mogfa_20
Snippet: Although several signaling pathways regulate autophagy, signaling from the cytoplasm to the autophagy machinery is controlled in a negative manner through serine/threonine kinase, a mTOR. Protein kinase B or Akt (PKB/Akt), a positive regulator of mTOR, suppresses the formation of autophagosomes and inhibits autophagy. 34 In addition, the Raf-1/MEK1/ extracellular signal-related kinase (ERK) 1/2 pathway is known to be involved in regulating autoph.....
Document: Although several signaling pathways regulate autophagy, signaling from the cytoplasm to the autophagy machinery is controlled in a negative manner through serine/threonine kinase, a mTOR. Protein kinase B or Akt (PKB/Akt), a positive regulator of mTOR, suppresses the formation of autophagosomes and inhibits autophagy. 34 In addition, the Raf-1/MEK1/ extracellular signal-related kinase (ERK) 1/2 pathway is known to be involved in regulating autophagy. 37 A recent study shows that inhibition of the pathway by a MAPK kinase (MAPKK) MEK1/2 inhibitor (PD98059), suppresses starvation-induced autophagy in the human colon cancer HT-29 cell line. 38 Our study clearly showed that METH inhibited the Akt/ mTOR/p70S6K pathway and activated the ERK signaling pathway, resulting in the induction of autophagy in endothelial cells (Figures 4 and 6) .
Search related documents:
Co phrase search for related documents- autophagosome formation and colon cancer: 1
- autophagy induction and cell line: 1, 2, 3, 4
- autophagy inhibit and cell line: 1
- autophagy inhibit and endothelial cell: 1
- autophagy machinery and cell line: 1
- cell line and colon cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- cell line and cytoplasm signal: 1
- cell line and endothelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell line and human colon cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell line and human colon cancer cell line: 1, 2, 3, 4, 5
- cell line and MAPK kinase: 1, 2, 3, 4, 5, 6, 7, 8
- colon cancer and endothelial cell: 1, 2
- colon cancer and human colon cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- colon cancer and human colon cancer cell line: 1, 2, 3, 4
- colon cancer and MAPK kinase: 1
- endothelial cell and MAPK kinase: 1, 2, 3, 4, 5, 6, 7, 8, 9
- ERK activate and MAPK kinase: 1, 2
Co phrase search for related documents, hyperlinks ordered by date