Selected article for: "cell line and pathway study"
Author: Ma, J; Wan, J; Meng, J; Banerjee, S; Ramakrishnan, S; Roy, S
Title: Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor
  • Document date: 2014_3_6
    • ID: wu2mogfa_20
    Snippet: Although several signaling pathways regulate autophagy, signaling from the cytoplasm to the autophagy machinery is controlled in a negative manner through serine/threonine kinase, a mTOR. Protein kinase B or Akt (PKB/Akt), a positive regulator of mTOR, suppresses the formation of autophagosomes and inhibits autophagy. 34 In addition, the Raf-1/MEK1/ extracellular signal-related kinase (ERK) 1/2 pathway is known to be involved in regulating autoph.....
    Document: Although several signaling pathways regulate autophagy, signaling from the cytoplasm to the autophagy machinery is controlled in a negative manner through serine/threonine kinase, a mTOR. Protein kinase B or Akt (PKB/Akt), a positive regulator of mTOR, suppresses the formation of autophagosomes and inhibits autophagy. 34 In addition, the Raf-1/MEK1/ extracellular signal-related kinase (ERK) 1/2 pathway is known to be involved in regulating autophagy. 37 A recent study shows that inhibition of the pathway by a MAPK kinase (MAPKK) MEK1/2 inhibitor (PD98059), suppresses starvation-induced autophagy in the human colon cancer HT-29 cell line. 38 Our study clearly showed that METH inhibited the Akt/ mTOR/p70S6K pathway and activated the ERK signaling pathway, resulting in the induction of autophagy in endothelial cells (Figures 4 and 6) .

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