Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_15
Snippet: In patients with unstable angina and myocardial infarction, the pro-inflammatory cytokines secreted by M1 phenotype macrophages were elevated, such as IL-6, with high levels predicating a poor outcome [46] . An in vitro study indicated that M1 phenotype macrophages could also induce smooth muscle cell proliferation and release of vasoactive molecules including NO, endothelins as well as eicosanoids, and they were important consequences for lipopr.....
Document: In patients with unstable angina and myocardial infarction, the pro-inflammatory cytokines secreted by M1 phenotype macrophages were elevated, such as IL-6, with high levels predicating a poor outcome [46] . An in vitro study indicated that M1 phenotype macrophages could also induce smooth muscle cell proliferation and release of vasoactive molecules including NO, endothelins as well as eicosanoids, and they were important consequences for lipoprotein oxidation and cytotoxicity [47, 48] . Early atherosclerotic plaques were infiltrated by M2 phenotype macrophages, however, along with the progression of the plaques, M1 phenotype macrophages gradually increased and occupied a major position [47] , thereby more likely leading to an acute atherothrombotic vascular accident.
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