Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_25
Snippet: Tumor-associated macrophages (TAM), the major component of those inflammatory cells infiltrated in cancer, play critical roles in the formation of cancer. In the stage of tumor initiation, TAM releases a large amount of inflammatory mediators to create an inflammatory environment and promote tumor growth. When tumors progress to malignancy, TAM contributes to the angiogenesis, invasion, metastasis of tumors, and decreases the anti-tumor immunity......
Document: Tumor-associated macrophages (TAM), the major component of those inflammatory cells infiltrated in cancer, play critical roles in the formation of cancer. In the stage of tumor initiation, TAM releases a large amount of inflammatory mediators to create an inflammatory environment and promote tumor growth. When tumors progress to malignancy, TAM contributes to the angiogenesis, invasion, metastasis of tumors, and decreases the anti-tumor immunity. As tumors become metastatic, TAM infiltrates the target tissues and makes beds for the arrival of tumor cells. In addition, some TAM even changes its phenotype to help extravasation, survival, and subsequent growth of tumor cells [64] .
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