Author: Chang, Stewart T.; Thomas, Matthew J.; Sova, Pavel; Green, Richard R.; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection Document date: 2013_2_5
ID: t98g8z7i_17
Snippet: Targets of microRNAs DE at early time points: cell cycle and transcriptional regulation. Many of the microRNAs DE early in infection (at 5 or 12 hpi) lacked published target mRNA predictions due to their recent discovery in the literature or limited degree of evolutionary conservation, which is suboptimal for algorithms such as TargetScan. To better characterize the early DE microRNAs, we generated an alternative set of TargetScan predictions usi.....
Document: Targets of microRNAs DE at early time points: cell cycle and transcriptional regulation. Many of the microRNAs DE early in infection (at 5 or 12 hpi) lacked published target mRNA predictions due to their recent discovery in the literature or limited degree of evolutionary conservation, which is suboptimal for algorithms such as TargetScan. To better characterize the early DE microRNAs, we generated an alternative set of TargetScan predictions using low evolutionary conservation thresholds and performed the correlation analysis between these microRNAs and their alternatively predicted target mRNAs.
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