Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA Document date: 2018_6_28
ID: tudwns0r_44
Snippet: In conclusion, it has been confirmed that small molecules can interact with E to give activity in both a target-based assay and a cell culture antiviral assay. The antiviral activity may be extended to other flaviviruses. These inhibitors have been used to give more information about the fusion process and to develop a target-based assay currently being used to drive medicinal chemistry efforts aimed at generating compounds suitable for in vivo v.....
Document: In conclusion, it has been confirmed that small molecules can interact with E to give activity in both a target-based assay and a cell culture antiviral assay. The antiviral activity may be extended to other flaviviruses. These inhibitors have been used to give more information about the fusion process and to develop a target-based assay currently being used to drive medicinal chemistry efforts aimed at generating compounds suitable for in vivo validation studies. Still to come, can E be validated as an antiviral target in vivo?
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