Author: Chu, Daniel K. W.; Hui, Kenrie P. Y.; Perera, Ranawaka A. P. M.; Miguel, Eve; Niemeyer, Daniela; Zhao, Jincun; Channappanavar, Rudragouda; Dudas, Gytis; Oladipo, Jamiu O.; Traoré, Amadou; Fassi-Fihri, Ouafaa; Ali, Abraham; Demissié, Getnet F.; Muth, Doreen; Chan, Michael C. W.; Nicholls, John M.; Meyerholz, David K.; Kuranga, Sulyman A.; Mamo, Gezahegne; Zhou, Ziqi; So, Ray T. Y.; Hemida, Maged G.; Webby, Richard J.; Roger, Francois; Rambaut, Andrew; Poon, Leo L. M.; Perlman, Stanley; Drosten, Christian; Chevalier, Veronique; Peiris, Malik
Title: MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Document date: 2018_3_20
ID: riitjx0f_22
Snippet: Differences in viral genes other than ORF4b or ORF3 genes likely contribute to the impaired viral replication of BF785 and Nig1657. MERS-CoV BF785 and Nig1657 differ from EMC in several proteins, including nsp1, nsp2, nsp3, nsp4, nsp5, nsp6, nsp7, nsp8, nsp12, nsp13, nsl14, nsp15 , and nsp16, the spike protein, ORF3/4/5 gene regions, and N protein (Dataset S2). The spike protein is a crucial determinant of virus tropism and interspecies transmiss.....
Document: Differences in viral genes other than ORF4b or ORF3 genes likely contribute to the impaired viral replication of BF785 and Nig1657. MERS-CoV BF785 and Nig1657 differ from EMC in several proteins, including nsp1, nsp2, nsp3, nsp4, nsp5, nsp6, nsp7, nsp8, nsp12, nsp13, nsl14, nsp15 , and nsp16, the spike protein, ORF3/4/5 gene regions, and N protein (Dataset S2). The spike protein is a crucial determinant of virus tropism and interspecies transmission. However, none of the amino acid differences between Arabian and West African viruses is in the receptor-binding interface.
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