Author: Baldwin, Don A.; Feldman, Michael; Alwine, James C.; Robertson, Erle S.
Title: Metagenomic Assay for Identification of Microbial Pathogens in Tumor Tissues Document date: 2014_9_16
ID: xlqdn0c7_4
Snippet: DNA microarrays have been used for metagenomics. The Lawrence Berkeley Lab/Affymetrix PhyloChip is based on rRNA sequences (19) . An academically developed Virochip has probes for 1,500-plus viruses (20, (38) (39) (40) (41) (42) (43) (44) and has successfully detected viruses in pathology samples. The Virochip platform is limited to viruses and assays RNA that is reverse transcribed to cDNA for PCR amplification (20, (38) (39) (40) (41) (42) (43).....
Document: DNA microarrays have been used for metagenomics. The Lawrence Berkeley Lab/Affymetrix PhyloChip is based on rRNA sequences (19) . An academically developed Virochip has probes for 1,500-plus viruses (20, (38) (39) (40) (41) (42) (43) (44) and has successfully detected viruses in pathology samples. The Virochip platform is limited to viruses and assays RNA that is reverse transcribed to cDNA for PCR amplification (20, (38) (39) (40) (41) (42) (43) (44) . The Glomics GeoChip 4.0 focuses on RNA expression by bacteria in the human microbiome (21) and covers bacteriophages but no other viruses, nor any eukaryotic microorganisms. PathGen Dx has launched a PathChip kit that features an Affymetrix microarray for all known viruses and a broad selection of bacteria (22) but no eukaryotic pathogens.
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