Selected article for: "foreign gene and important role"
Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes
  • Document date: 2019_11_14
    • ID: vv5gpldi_67
    Snippet: When introducing GFP into the five variable regions of HIV-1, certain regions (V4 and V5) were more tolerant to foreign gene insertions than the other variable regions (V1, V2, and V3) (Nakane, Iwamoto, and Matsuda 2015) . In particular, GFP insertions into the V3 region showed lower levels of expression (Nakane, Iwamoto, and Matsuda 2015) , which is consistent with V3 having the lowest indel rate (Palmer and Poon 2018) , thus having a lower stab.....
    Document: When introducing GFP into the five variable regions of HIV-1, certain regions (V4 and V5) were more tolerant to foreign gene insertions than the other variable regions (V1, V2, and V3) (Nakane, Iwamoto, and Matsuda 2015) . In particular, GFP insertions into the V3 region showed lower levels of expression (Nakane, Iwamoto, and Matsuda 2015) , which is consistent with V3 having the lowest indel rate (Palmer and Poon 2018) , thus having a lower stability after gene insertions. This piece of empirical evidence again shows that the site of insertion plays an important role in determining expression levels and stability.

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