Selected article for: "multiple trigger wheeze and recurrent wheeze"
Author: Kim, Chang-Keun; Callaway, Zak; Park, Jin-Sung; Nishimori, Hisashi; Ogino, Tikatoshi; Nagao, Mizuho; Fujisawa, Takao
Title: Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma
  • Document date: 2018_8_30
    • ID: uzge50xu_31
    Snippet: This study clearly demonstrated that preschool children with beta2-agonist responsive recurrent wheeze and multiple-trigger wheeze, a high EDN level, and HDM sensitivity responded well to both montelukast and budesonide. As expected, montelukast treatment significantly reduced sEDN levels. Unexpectedly, BIS treatment did not. Both treatments also resulted in significant decreases in rescue medication usage over the treatment period. In terms of c.....
    Document: This study clearly demonstrated that preschool children with beta2-agonist responsive recurrent wheeze and multiple-trigger wheeze, a high EDN level, and HDM sensitivity responded well to both montelukast and budesonide. As expected, montelukast treatment significantly reduced sEDN levels. Unexpectedly, BIS treatment did not. Both treatments also resulted in significant decreases in rescue medication usage over the treatment period. In terms of clinical outcomes, montelukast was as effective as budesonide in the biomarkerdefined (i.e., mite sensitized, eosinophilic asthma) subpopulation of preschool asthmatics.

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