Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_12
Snippet: CD46 is a cell-surface, type I transmembrane 57-67 kD glycoprotein that belongs to the family of complement activation regulators and is ubiquitously expressed in all nucleated human cells. The most important function of CD46 is as an inhibitor of complement activation. It protects host cells from complement deposition by functioning as a cofactor for the factor-I-mediated proteolytic inactivation of C3b and C4b (Liszewski et al., 1991) . In addi.....
Document: CD46 is a cell-surface, type I transmembrane 57-67 kD glycoprotein that belongs to the family of complement activation regulators and is ubiquitously expressed in all nucleated human cells. The most important function of CD46 is as an inhibitor of complement activation. It protects host cells from complement deposition by functioning as a cofactor for the factor-I-mediated proteolytic inactivation of C3b and C4b (Liszewski et al., 1991) . In addition, CD46 has been implicated in the modulation of T-cell functions (Marie et al., 2002) , generation of regulatory T-cells (Kemper et al., 2003) , and control of interferon (IFN) production (Katayama et al., 2000) . CD46 is also important during fertilization -it presumably promotes sperm-egg interaction (Riley-Vargas et al., 2004 Harris et al., 2006) .
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