Selected article for: "bone formation and gene expression"
Author: Xi, Hongbo; Tao, Weijian; Jian, Zhengguang; Sun, Xuefeng; Gong, Xiaohong; Huang, Lixin; Dong, Tianhua
Title: Levodopa attenuates cellular apoptosis in steroid-associated necrosis of the femoral head
  • Document date: 2016_12_7
    • ID: z105jy9g_31
    Snippet: Hill et al (20) considered that there were a variety of extracellular signals that may affect the viability of osteoblasts. For example, lacking GF, IGF and bone nutrients results in osteoblasts prematurely entering apoptosis; whereas IGF-1, insulin and basic fibroblast growth factor are able to prevent the apoptosis of osteoblasts. Tumor necrosis factor-α may promote the apoptosis of osteoblasts, among which IGF-1 has been demonstrated to be on.....
    Document: Hill et al (20) considered that there were a variety of extracellular signals that may affect the viability of osteoblasts. For example, lacking GF, IGF and bone nutrients results in osteoblasts prematurely entering apoptosis; whereas IGF-1, insulin and basic fibroblast growth factor are able to prevent the apoptosis of osteoblasts. Tumor necrosis factor-α may promote the apoptosis of osteoblasts, among which IGF-1 has been demonstrated to be one of the major growth factors that promotes bone formation. Glucocorticoids are able to inhibit IGF-1 gene transcription inside osteoblasts, thereby regulating the expression of IGF-1 in osteoblasts.

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