Selected article for: "low concentration and lysosomal damage"

Author: Ding, Peiyang; Zhang, Teng; Li, Yafei; Teng, Man; Sun, Yaning; Liu, Xiao; Chai, Shujun; Zhou, Enmin; Jin, Qianyue; Zhang, Gaiping
Title: Nanoparticle orientationally displayed antigen epitopes improve neutralizing antibody level in a model of porcine circovirus type 2
  • Document date: 2017_7_24
  • ID: upb97on4_46
    Snippet: Nanoparticles orientationally display neutralizing epitopes release of IL-12 and TNF-α. Inflammasomes are known to be activated on exposure to nanoparticles due to lysosomal damage. We focused on IL-1β and IL-18, which promote inflammatory responses and are tightly regulated by inflammasomes. The concentration of IL-1β and IL-18 were low indicating no inflammasomes were produced after uptake of AuNPs by RAW264.7 cells......
    Document: Nanoparticles orientationally display neutralizing epitopes release of IL-12 and TNF-α. Inflammasomes are known to be activated on exposure to nanoparticles due to lysosomal damage. We focused on IL-1β and IL-18, which promote inflammatory responses and are tightly regulated by inflammasomes. The concentration of IL-1β and IL-18 were low indicating no inflammasomes were produced after uptake of AuNPs by RAW264.7 cells.

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