Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_20
Snippet: Substantial evidences demonstrate that obesity is a chronic low-grade inflammatory disease [56] . An important initiator of the inflammatory reaction to obesity is adipose tissue, which is consisting of adipocytes, preadipocytes, endothelial cells and immune cells (e.g., macrophages and lymphocytes). In obesity, adipocytes can release pro-inflammatory mediators, such as CC chemokine ligand (CCL)-2, TNF-α, free fatty acids (FFAs), instead of lept.....
Document: Substantial evidences demonstrate that obesity is a chronic low-grade inflammatory disease [56] . An important initiator of the inflammatory reaction to obesity is adipose tissue, which is consisting of adipocytes, preadipocytes, endothelial cells and immune cells (e.g., macrophages and lymphocytes). In obesity, adipocytes can release pro-inflammatory mediators, such as CC chemokine ligand (CCL)-2, TNF-α, free fatty acids (FFAs), instead of leptin and adiponectin which promote insulin sensitivity in normal state [57] . Those pro-inflammatory mediators induce the recruitment and activation of adipose tissue macrophage (ATM). The activated ATM secrets pro-inflammatory cytokines and forms the inflammatory circuit which blocks the insulin action of adipocytes and leads to insulin resistance [58] .
Search related documents:
Co phrase search for related documents- activation recruitment and chemokine ligand: 1, 2, 3, 4
- activation recruitment and endothelial cell: 1, 2, 3, 4, 5
- activation recruitment and immune cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- activation recruitment and inflammatory disease: 1, 2, 3, 4, 5, 6, 7, 8
- activation recruitment and insulin resistance: 1
- activation recruitment and low grade: 1
- activation recruitment and pro inflammatory cytokine: 1, 2, 3
- activation recruitment and tissue macrophage: 1
- adipose tissue and cc chemokine ligand: 1
- adipose tissue and chemokine ligand: 1, 2
- adipose tissue and endothelial cell: 1, 2, 3
- adipose tissue and fatty acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- adipose tissue and free fatty acid: 1, 2, 3
- adipose tissue and immune cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- adipose tissue and inflammatory disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- adipose tissue and inflammatory reaction: 1
- adipose tissue and insulin action: 1, 2
- adipose tissue and insulin resistance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61
- adipose tissue and insulin sensitivity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
Co phrase search for related documents, hyperlinks ordered by date