Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_39
Snippet: Macrophage is an attractive therapeutic target, but it is necessary to understand their phenotypes according to their characteristics, anatomical location and origins (yolk sac, fetal liver, bone marrow) [11] . The microenvironment can regulate the phenotype and function of macrophages from their progenitors, lineage-specific differentiation to the fully differentiated stage [98] . Though organs contained resident tissue macrophages could be repl.....
Document: Macrophage is an attractive therapeutic target, but it is necessary to understand their phenotypes according to their characteristics, anatomical location and origins (yolk sac, fetal liver, bone marrow) [11] . The microenvironment can regulate the phenotype and function of macrophages from their progenitors, lineage-specific differentiation to the fully differentiated stage [98] . Though organs contained resident tissue macrophages could be replenished after infection and other forms of tissue injury, the mechanisms that control initiation and differentiation of macrophage subsets remain mysterious. Future research should pay more attention to the anatomical location and the microenvironment of macrophage to restore the balance status.
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