Selected article for: "clinical disease activity and disease activity"
Author: Kent, A. C. C.; Cross, G.; Taylor, D. R.; Sherwood, R. A.; Watson, P. J.
Title: Measurement of serum 7a-hydroxy-4-cholesten-3-one as a marker of bile acid malabsorption in dogs with chronic diarrhoea: a pilot study
  • Document date: 2016_4_6
    • ID: rkdfde07_22
    Snippet: We hypothesised that there may be a relationship between an elevated serum C4 concentration and hypocobalaminaemia, based on the knowledge that both abnormalities may be associated with distal small intestinal disease (Berghoff and others 2013) ; however, there was no evidence of such a relationship. One of the cases with particularly high serum C4 concentration did have a very low serum cobalamin, suggesting that significant distal small intesti.....
    Document: We hypothesised that there may be a relationship between an elevated serum C4 concentration and hypocobalaminaemia, based on the knowledge that both abnormalities may be associated with distal small intestinal disease (Berghoff and others 2013) ; however, there was no evidence of such a relationship. One of the cases with particularly high serum C4 concentration did have a very low serum cobalamin, suggesting that significant distal small intestinal pathology may lead to both these changes in some cases. There was also no evidence of an association between the clinical severity of the disease, as measured by the clinical activity index, and serum C4 concentration. However, the numbers were very small in this pilot study, which was significantly underpowered to find any associations, as demonstrated by the post hoc power estimations.

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