Author: Wu, Beibei; Wang, Liyin; Jiang, Lili; Dong, Lili; Xu, Fengli; Lu, Yili; Jin, Jiahui; Wang, Zhanyue; Liang, Guang; Shan, Xiaoou
Title: n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils Document date: 2017_10_25
ID: w85t4zz6_25
Snippet: In conclusion, the present study demonstrated that n-butanol extract obtained from F. isatidis prevented the LPS-induced downregulation of CXCR1, CXCR2 and CD62L on neutrophils. The extract promoted neutrophil migration in response to IL-8. These results indicated that n-butanol extract from F. isatidis, which targets neutrophil chemotaxis during LPS-induced sepsis, is a potential candidate for the treatment of sepsis......
Document: In conclusion, the present study demonstrated that n-butanol extract obtained from F. isatidis prevented the LPS-induced downregulation of CXCR1, CXCR2 and CD62L on neutrophils. The extract promoted neutrophil migration in response to IL-8. These results indicated that n-butanol extract from F. isatidis, which targets neutrophil chemotaxis during LPS-induced sepsis, is a potential candidate for the treatment of sepsis.
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