Author: Morgan, Brittany S; Forte, Jordan E; Hargrove, Amanda E
Title: Insights into the development of chemical probes for RNA Document date: 2018_9_19
ID: wupre5uj_13
Snippet: Small molecules discovered by HTS were typically from large libraries (n > 50 000 small molecules), including three corporate libraries and the NIH Small Molecule Repository [ Table 1 ]. There were select examples of smaller libraries as well: FDA-approved drugs (n = 1120) and UCLA academic library (n = 1692). Importantly, some of these reports explicitly stated that libraries were filtered to yield small molecules with favorable medicinal chemis.....
Document: Small molecules discovered by HTS were typically from large libraries (n > 50 000 small molecules), including three corporate libraries and the NIH Small Molecule Repository [ Table 1 ]. There were select examples of smaller libraries as well: FDA-approved drugs (n = 1120) and UCLA academic library (n = 1692). Importantly, some of these reports explicitly stated that libraries were filtered to yield small molecules with favorable medicinal chemistry proper-
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