Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress Document date: 2017_2_28
ID: w731ehtz_10
Snippet: The p53 tumor suppressor coordinates cellular responses to DNA damage as well as to other stresses, such as abnormal oncogene activation, telomere erosion, and hypoxia (Green and Kroemer, 2009; Riley et al., 2008) . Under normal conditions, the level of p53 protein is kept low by several E3 ligases-mediated ubiquitination. Among them, MDM2 is the major ubiquitin E3 ligase that leads to degradation of p53 by proteasome. Interestingly, the expressi.....
Document: The p53 tumor suppressor coordinates cellular responses to DNA damage as well as to other stresses, such as abnormal oncogene activation, telomere erosion, and hypoxia (Green and Kroemer, 2009; Riley et al., 2008) . Under normal conditions, the level of p53 protein is kept low by several E3 ligases-mediated ubiquitination. Among them, MDM2 is the major ubiquitin E3 ligase that leads to degradation of p53 by proteasome. Interestingly, the expression of MDM2 is induced by p53, thus forming a negative feedback loop for down-regulation of p53 (Ashcroft and Vousden, 1999; Oliner et al., 1992; Wu et al., 1993) . Under stressed conditions, however, the interaction of p53 with MDM2 and other negative regulators is disrupted by phosphorylation and acetylation, leading to stabilization and activation of p53.
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