Selected article for: "H1N1 influenza and human influenza"
Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines
  • Document date: 2017_7_26
    • ID: vk59ghjm_18
    Snippet: NDV-vectored vaccines may be useful against human influenza viruses. Nakaya et al. [35] developed a NDV-vectored human influenza vaccine (rNDV/B1-HA) expressing the HA protein of A/WSN/33 influenza virus (H1N1). Two intravenous inoculations of mice with the rNDV/B1-HA vaccine (3×10 7 PFU/dose) induced a strong anti-influenza virus antibody response and provided complete protection against lethal challenge with influenza A/WSN/33 virus. Recently,.....
    Document: NDV-vectored vaccines may be useful against human influenza viruses. Nakaya et al. [35] developed a NDV-vectored human influenza vaccine (rNDV/B1-HA) expressing the HA protein of A/WSN/33 influenza virus (H1N1). Two intravenous inoculations of mice with the rNDV/B1-HA vaccine (3×10 7 PFU/dose) induced a strong anti-influenza virus antibody response and provided complete protection against lethal challenge with influenza A/WSN/33 virus. Recently, DiNapoli et al. [36] developed a NDV-vectored HPAIV vaccine (NDV-HA) expressing the HA protein of A/Vietnam/1203/04(H5N1) HPAIV for use in humans. Its protective efficacy against HPAIV was evaluated in an African green monkey model. Two oro-nasal administrations of NDV-HA (2×10 7 PFU/dose) induced a high serum titer of HPAIV neutralizing antibodies and a robust mucosal immunoglobulin A response in the respiratory tract. These results suggest that NDV-HA may be an effective human vaccine for HPAIV.

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