Selected article for: "AIV vaccine and field virulent"

Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines
  • Document date: 2017_7_26
  • ID: vk59ghjm_27
    Snippet: NDV vector vaccines expressing the HA gene of HPAIV show high protective efficacy against HPAIV and virulent NDV in experimental SPF chickens [45, 50] ; however, under field con- ditions most breeders maintain a high level of immunity to NDV through multiple vaccinations, ensuring that progeny chicks have maternal antibodies to NDV for the first few weeks of life. However, the presence of maternal antibodies could interfere with the efficacy of t.....
    Document: NDV vector vaccines expressing the HA gene of HPAIV show high protective efficacy against HPAIV and virulent NDV in experimental SPF chickens [45, 50] ; however, under field con- ditions most breeders maintain a high level of immunity to NDV through multiple vaccinations, ensuring that progeny chicks have maternal antibodies to NDV for the first few weeks of life. However, the presence of maternal antibodies could interfere with the efficacy of the NDV-vectored AIV vaccine, resulting in poor antibody responses to NDV and AIV HA. As an alternative strategy, chimeric NDV-vectored vaccines, in which the ectodomains of F and HN proteins are replaced by those of another avian paramyxovirus serotype, have been developed [51, 56] .

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