Selected article for: "differential expression and host gene"
Author: Chang, Stewart T.; Sova, Pavel; Peng, Xinxia; Weiss, Jeffrey; Law, G. Lynn; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4(+) T Cell Line
  • Document date: 2011_9_20
    • ID: zyzgk2z3_22
    Snippet: We also observed differential expression of four annotated mi-croRNA host genes in infected cells, three of which were downregulated (MIR17HG, MIR142, and MIR621), while the remaining one was upregulated (MIR518F), all with 2-fold or greater changes. The downregulation of MIR17HG (by 2.25-fold) was of particular interest, as MIR17HG encodes a cluster of microRNAs, including miR-17, -18A, -19A, -19B, -20A, and -92 (Fig. 4B) ; in contrast, the othe.....
    Document: We also observed differential expression of four annotated mi-croRNA host genes in infected cells, three of which were downregulated (MIR17HG, MIR142, and MIR621), while the remaining one was upregulated (MIR518F), all with 2-fold or greater changes. The downregulation of MIR17HG (by 2.25-fold) was of particular interest, as MIR17HG encodes a cluster of microRNAs, including miR-17, -18A, -19A, -19B, -20A, and -92 (Fig. 4B) ; in contrast, the other microRNA host genes encode only single microRNAs. Reads mapped to MIR17HG 3= of the mature microRNA sequences, indicating that the postexcised polyadenylated product may have been detected (Fig. 4B) . We also observed a concurrent upregulation of known targets of MIR17HGencoded microRNAs, including PCAF, a host factor required for Tat-induced HIV-1 gene expression (25) .

    Search related documents:
    Co phrase search for related documents
    • concurrent upregulation and host factor: 1
    • concurrent upregulation and host gene: 1
    • concurrent upregulation and microRNA host gene: 1
    • concurrent upregulation and microRNAs cluster: 1
    • differential expression and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • differential expression and host factor: 1, 2, 3, 4
    • differential expression and host gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • differential expression and infected cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
    • differential expression and infected cell host gene: 1
    • differential expression and microRNA host gene: 1
    • differential expression and microRNAs cluster: 1
    • gene expression and host factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and host gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and infected cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and infected cell host gene: 1
    • gene expression and particular interest: 1, 2, 3, 4, 5, 6, 7
    • host factor and infected cell: 1, 2, 3, 4
    • host factor and microRNA host gene: 1
    • host factor and microRNAs cluster: 1