Author: Chang, Stewart T.; Sova, Pavel; Peng, Xinxia; Weiss, Jeffrey; Law, G. Lynn; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4(+) T Cell Line Document date: 2011_9_20
ID: zyzgk2z3_22
Snippet: We also observed differential expression of four annotated mi-croRNA host genes in infected cells, three of which were downregulated (MIR17HG, MIR142, and MIR621), while the remaining one was upregulated (MIR518F), all with 2-fold or greater changes. The downregulation of MIR17HG (by 2.25-fold) was of particular interest, as MIR17HG encodes a cluster of microRNAs, including miR-17, -18A, -19A, -19B, -20A, and -92 (Fig. 4B) ; in contrast, the othe.....
Document: We also observed differential expression of four annotated mi-croRNA host genes in infected cells, three of which were downregulated (MIR17HG, MIR142, and MIR621), while the remaining one was upregulated (MIR518F), all with 2-fold or greater changes. The downregulation of MIR17HG (by 2.25-fold) was of particular interest, as MIR17HG encodes a cluster of microRNAs, including miR-17, -18A, -19A, -19B, -20A, and -92 (Fig. 4B) ; in contrast, the other microRNA host genes encode only single microRNAs. Reads mapped to MIR17HG 3= of the mature microRNA sequences, indicating that the postexcised polyadenylated product may have been detected (Fig. 4B) . We also observed a concurrent upregulation of known targets of MIR17HGencoded microRNAs, including PCAF, a host factor required for Tat-induced HIV-1 gene expression (25) .
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