Selected article for: "cell entry and enhanced infection"

Author: Gunn, Michael D.; Kyuwa, Shigeru; Tam, Carmen; Kakiuchi, Terutaka; Matsuzawa, Akio; Williams, Lewis T.; Nakano, Hideki
Title: Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
  • Document date: 1999_2_1
  • ID: sz28ar3t_22
    Snippet: plt Mice Have Decreased Resistance to Viral Infection. The entry of lymphocytes and DCs into T cell zones is likely to be a critical step in the development of a primary immune response. Because plt mice have defects in lymphocyte and DC migration, they are predicted to be deficient in mounting such a response. To evaluate the response of plt mice to viral infection, these mice were infected with MHV administered by intraperitoneal injection. plt.....
    Document: plt Mice Have Decreased Resistance to Viral Infection. The entry of lymphocytes and DCs into T cell zones is likely to be a critical step in the development of a primary immune response. Because plt mice have defects in lymphocyte and DC migration, they are predicted to be deficient in mounting such a response. To evaluate the response of plt mice to viral infection, these mice were infected with MHV administered by intraperitoneal injection. plt mice demonstrate a markedly enhanced sensitivity to viral infection (Fig. 8) . At a dose of 20 PFU, which causes no mortality in wild-type mice, 80% of the infected plt mice died. The LD 50 for MHV in wild-type mice was calculated to be 1,840 PFU. In plt mice the LD 50 for MHV was 5.67 PFU, a 300-fold decrease.

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