Author: Roman Woelfel; Victor Max Corman; Wolfgang Guggemos; Michael Seilmaier; Sabine Zange; Marcel A Mueller; Daniela Niemeyer; Patrick Vollmar; Camilla Rothe; Michael Hoelscher; Tobias Bleicker; Sebastian Bruenink; Julia Schneider; Rosina Ehmann; Katrin Zwirglmaier; Christian Drosten; Clemens Wendtner
Title: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster Document date: 2020_3_8
ID: gunn55f9_25
Snippet: The combination of very high virus RNA concentrations and occasional detection of sgRNAcontaining cells in stool indicate active replication in the gastrointestinal tract. Active replication is also suggested by a much higher detection rate as compared to MERScoronavirus, for which we found stool-associated RNA in only 14.6% samples in 37 patients hospitalized in Riyadh, Saudi Arabia 21,22 . If virus was only passively present in stool, such as a.....
Document: The combination of very high virus RNA concentrations and occasional detection of sgRNAcontaining cells in stool indicate active replication in the gastrointestinal tract. Active replication is also suggested by a much higher detection rate as compared to MERScoronavirus, for which we found stool-associated RNA in only 14.6% samples in 37 patients hospitalized in Riyadh, Saudi Arabia 21,22 . If virus was only passively present in stool, such as after swallowing respiratory secretions, similar detection rates as for MERS-CoV would be expected. Replication in the gastrointestinal tract is also supported by analogy with SARS-CoV, which was regularly excreted in stool, from which it could be isolated in cell culture 23 .
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