Title: Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network Document date: 1991_12_2
ID: syyi2ysq_46
Snippet: This allowed us to compare the effect of nonaggregative and aggregative milieu on the release of these proteins, which have molecular weights and isoelectric points similar to those of CgB and SgII (Lee, 1987) , and which like the granins bind calcium (Macer and Koch, 1988) . In contrast to CgB and SgII (see Fig. 1 A) , the release of the ER-resident proteins was not reduced by aggregative milieu compared to nonaggregative milieu (Fig. 5, right p.....
Document: This allowed us to compare the effect of nonaggregative and aggregative milieu on the release of these proteins, which have molecular weights and isoelectric points similar to those of CgB and SgII (Lee, 1987) , and which like the granins bind calcium (Macer and Koch, 1988) . In contrast to CgB and SgII (see Fig. 1 A) , the release of the ER-resident proteins was not reduced by aggregative milieu compared to nonaggregative milieu (Fig. 5, right panels) . This also showed that permeabilization of membranes with saponin was not impaired in aggregative milieu .
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