Author: Glennie, S; Gritzfeld, J F; Pennington, S H; Garner-Jones, M; Coombes, N; Hopkins, M J; Vadesilho, C F; Miyaji, E N; Wang, D; Wright, A D; Collins, A M; Gordon, S B; Ferreira, D M
Title: Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage Document date: 2015_4_29
ID: st475jw7_1
Snippet: Secondary bacterial infections with Streptococcus pneumoniae are a major cause of morbidity and mortality during pandemic influenza. 1 Pneumococcus commonly colonizes the upper respiratory tract (URT) in healthy individuals but viral infections transform this normally harmless commensal organism into a potentially fatal pathogen by increasing pneumococcal transmission, 2 carriage density, 3, 4 and host disease susceptibility. 5 The current threat.....
Document: Secondary bacterial infections with Streptococcus pneumoniae are a major cause of morbidity and mortality during pandemic influenza. 1 Pneumococcus commonly colonizes the upper respiratory tract (URT) in healthy individuals but viral infections transform this normally harmless commensal organism into a potentially fatal pathogen by increasing pneumococcal transmission, 2 carriage density, 3, 4 and host disease susceptibility. 5 The current threat of influenza pandemics, increasing antibiotic resistance, and the burden of coinfection in the young and aged populations make it critical to understand how viral infection increases susceptibility to pneumococcal disease.
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