Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma

Kim, Chang-Keun; Callaway, Zak; Park, Jin-Sung; Nishimori, Hisashi; Ogino, Tikatoshi; Nagao, Mizuho; Fujisawa, Takao

Chronic airway inflammation is a hallmark of asthma 1 ; consequently, inhaled corticosteroids (ICSs) are the main treatment. 2 Although leukotriene receptor antagonists (LTRAs) also have anti-inflammatory properties 3 and are often administered, especially to young children, guidelines clearly state ICSs are the preferred option for long-term control of asthma. 2 This preference is based mainly on evidence from clinical trials comparing mean responses between treatment and control groups. However, other trials have demonstrated that there is considerable inter-individual variability in treatment response to ICSs versus LTRAs. [4] [5] [6] It is important for a clinician to collect information that better guides them in selecting medication most likely to achieve a favorable response in each patient (i.e., tailor-made treatment regimens).