Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma

Kim, Chang-Keun; Callaway, Zak; Park, Jin-Sung; Nishimori, Hisashi; Ogino, Tikatoshi; Nagao, Mizuho; Fujisawa, Takao

Within group analyses of ACD at multiple time points during the entire study period (−2 to 12 weeks) were compared using 2-way ANOVA, followed by Sidak's multiple comparisons test. This was only done for the BIS and MONT groups. Between-group analyses of ACD (BIS versus MONT groups) were done using the Wilcoxon matched-pairs signed rank test. Within group analyses of treatment effect comparing "Pre" (measured during run-in period −2 to 0 week) and "Post" (measured at 12 weeks) measurements of changes in sEDN for all 3 groups (BIS, MONT and OBS) were done using the Wilcoxon matched-pairs signed rank test. Each group was then subgrouped according to presence or absence of any virus and change in sEDN with treatment from "Pre" to "Post" was analyzed using the same statistical test. Rescue medication usage within each group (BIS and MONT) and between each group were also compared. Data that were normally distributed were presented as mean values, unless otherwise noted. P values < 0.05 were considered statistically significant. Fig. 2 .