Author: Chang, Stewart T.; Thomas, Matthew J.; Sova, Pavel; Green, Richard R.; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection Document date: 2013_2_5
ID: t98g8z7i_3
Snippet: HIV infection has been shown to alter microRNA expression, both in cultured cells and in peripheral blood mononuclear cells (PBMCs) isolated ex vivo, e.g., in references 5 and 6. However, technologies such as microarrays that were used in previous studies limited identifications to known, annotated microRNAs. NGS applied to small RNA (small RNA-Seq) circumvents this limitation, detecting microRNAs without the need for prior annotation as well as .....
Document: HIV infection has been shown to alter microRNA expression, both in cultured cells and in peripheral blood mononuclear cells (PBMCs) isolated ex vivo, e.g., in references 5 and 6. However, technologies such as microarrays that were used in previous studies limited identifications to known, annotated microRNAs. NGS applied to small RNA (small RNA-Seq) circumvents this limitation, detecting microRNAs without the need for prior annotation as well as extending quantitation over a wider dynamic range. Indeed, sequencing has contributed recently to an expansion in the number of known microRNAs (7) .
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