Author: Rathore, Shailendra S.; Liu, Yinghui; Yu, Haijia; Wan, Chun; Lee, MyeongSeon; Yin, Qian; Stowell, Michael H.B.; Shen, Jingshi
Title: Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE Document date: 2019_12_24
ID: pudp1eoo_15
Snippet: Together, these data demonstrate that both the basic and hydrophobic stretches are required for the function of the VAMP2 juxtamembrane motif in SNARE-Munc18-1-mediated membrane fusion. Because these regions are known to interact with lipids Brewer et al., 2011; Ellena et al., 2009) , our data further suggest that the juxtamembrane motif promotes membrane fusion by directly binding to the lipid bilayer......
Document: Together, these data demonstrate that both the basic and hydrophobic stretches are required for the function of the VAMP2 juxtamembrane motif in SNARE-Munc18-1-mediated membrane fusion. Because these regions are known to interact with lipids Brewer et al., 2011; Ellena et al., 2009) , our data further suggest that the juxtamembrane motif promotes membrane fusion by directly binding to the lipid bilayer.
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