Author: Rathore, Shailendra S.; Liu, Yinghui; Yu, Haijia; Wan, Chun; Lee, MyeongSeon; Yin, Qian; Stowell, Michael H.B.; Shen, Jingshi
Title: Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE Document date: 2019_12_24
ID: pudp1eoo_28
Snippet: The juxtamembrane region of the t-SNARE subunit syntaxin also positively regulates exocytosis (Lam et al., 2008; Singer-Lahat et al., 2018; van den Bogaart et al., 2011; Van Komen et al., 2005) . However, this region lacks a hydrophobic stretch and is not known to penetrate into the surface of membrane bilayers (Lam et al., 2008) . Thus, the juxtamembrane region of syntaxin may not act as a membrane-destabilizing peptide in the fusion reaction. I.....
Document: The juxtamembrane region of the t-SNARE subunit syntaxin also positively regulates exocytosis (Lam et al., 2008; Singer-Lahat et al., 2018; van den Bogaart et al., 2011; Van Komen et al., 2005) . However, this region lacks a hydrophobic stretch and is not known to penetrate into the surface of membrane bilayers (Lam et al., 2008) . Thus, the juxtamembrane region of syntaxin may not act as a membrane-destabilizing peptide in the fusion reaction. Instead, the lipid-binding activity of this region may regulate syntaxin localization and/or modulate other exocytic factors. As discussed above, the juxtamembrane motif of the v-SNARE may bind and destabilize the target membrane in trans after its dislodging from the vesicle membrane, promoting lipid rearrangements in both membrane bilayers.
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