Selected article for: "synthetic biology and wide range"

Author: DiMaio, Daniel
Title: Is Virology Dead?
  • Document date: 2014_3_25
  • ID: ykb2s5ja_7
    Snippet: We can also learn from viruses how to alter cell function. Viral proteins can be used to modulate cell behavior, and the design of novel proteins modeled on viral proteins is a new frontier in synthetic biology. A small papillomavirus protein has been used as an all-purpose transmembrane scaffold to reprogram cells to undergo red blood cell differentiation or to resist HIV infection, and plans are afoot to utilize a small adenovirus protein to ma.....
    Document: We can also learn from viruses how to alter cell function. Viral proteins can be used to modulate cell behavior, and the design of novel proteins modeled on viral proteins is a new frontier in synthetic biology. A small papillomavirus protein has been used as an all-purpose transmembrane scaffold to reprogram cells to undergo red blood cell differentiation or to resist HIV infection, and plans are afoot to utilize a small adenovirus protein to manipulate a wide range of nuclear functions (19) (20) (21) . Finally, the small size of viral genomes permits us to construct "designer viruses" in the (to the dismay of some) to plumb their secrets, and we can customize viral genomes to meet our needs, such as the rational attenuation of vaccine strains (23, 24) .

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