Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_29
Snippet: Additionally, the expression of the pr protein also successfully inhibited virus fusion at low pH and stopped viral infection [146] . Approximately 81-85% inhibition was achieved at 30 µM. Data indicated that the pr peptide interacted with a highly conserved histidine (H244) because the substitution of H244 to alanine had led to the disruption of the pr-E interaction [146] . This disruption could have resulted in a distorted E conformation, ther.....
Document: Additionally, the expression of the pr protein also successfully inhibited virus fusion at low pH and stopped viral infection [146] . Approximately 81-85% inhibition was achieved at 30 µM. Data indicated that the pr peptide interacted with a highly conserved histidine (H244) because the substitution of H244 to alanine had led to the disruption of the pr-E interaction [146] . This disruption could have resulted in a distorted E conformation, therefore interfering the pH-triggered fusion reaction in the endosome. Further optimization could be carried out using truncated pr peptides to identify the amino acid residues that are essential to block viral infection.
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