Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_40
Snippet: In vitro studies have shown that a number of SLAM-negative cell types of epithelial or neuronal origin result in cytopathic effects and virus release. In particular, several well-differentiated polarized epithelial cell lines showed high susceptibility to wild-type MeV (Takeda et al., 2007; Tahara et al., 2008) . Further in vitro studies indicated that wild-type MeV enters human polarized airway epithelium basolaterally, whereas progeny viral par.....
Document: In vitro studies have shown that a number of SLAM-negative cell types of epithelial or neuronal origin result in cytopathic effects and virus release. In particular, several well-differentiated polarized epithelial cell lines showed high susceptibility to wild-type MeV (Takeda et al., 2007; Tahara et al., 2008) . Further in vitro studies indicated that wild-type MeV enters human polarized airway epithelium basolaterally, whereas progeny viral particles are released exclusively from the apical surface of these cells (Tahara et al., 2008; Ludlow et al., 2010) . Moreover, it was shown that loss of tight junction proteins induced by the transcription repressor SNAIL blocked infection with MeV (Shirogane et al., 2010) . These data strongly implied that polarized epithelial cells possess a putative epithelial receptor, EpR, and that the receptor appears to be expressed on the basolateral side of the cells that is associated with tight junctions.
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