Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_9
Snippet: For instance, advances in automated-liquid handling devices, synthetic peptide synthesis, mass spectrometry and in silico drug design have allowed high-throughput drug screening. In addition, advances in peptide manipulations such as synthesis of D-amino acids, cyclic peptides, incorporation of chemicals and nanocarriers have further increased the bioavailability of peptides [53] . Currently, ample examples of efficacious and safe peptide drugs a.....
Document: For instance, advances in automated-liquid handling devices, synthetic peptide synthesis, mass spectrometry and in silico drug design have allowed high-throughput drug screening. In addition, advances in peptide manipulations such as synthesis of D-amino acids, cyclic peptides, incorporation of chemicals and nanocarriers have further increased the bioavailability of peptides [53] . Currently, ample examples of efficacious and safe peptide drugs are available in the market [54] [55] [56] [57] . Great success has been achieved for the peptide drug Fuzeon TM (enfuvirtide), a synthetic peptide that blocks viral fusion by binding to the gp41 (polypeptide chain) of the human immunodeficiency virus (HIV) type-1 envelope protein [55] . It is the only antiviral peptide which has been commercialised. Other antimicrobial peptide candidates, such as MU1140, Arenicin, IMX924, Novexatin and Lytixar, are being evaluated in the preclinical and clinical trials [58, 59] . Myrcludex B, an anti-Hepatitis B and Hepatitis D targeting sodium taurocholate co-transporting polypeptide (NTCP) of liver cells, is also being studied in a phase II clinical trial [60] .
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