Author: Wu, Beibei; Wang, Liyin; Jiang, Lili; Dong, Lili; Xu, Fengli; Lu, Yili; Jin, Jiahui; Wang, Zhanyue; Liang, Guang; Shan, Xiaoou
Title: n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils Document date: 2017_10_25
ID: w85t4zz6_20
Snippet: As previously reported, the present study observed that LPS stimulation decreased the expression of CXCR1, CXCR2 and CD62L on neutrophils. In addition to being effector cells involved in the acute phase of the inflammatory response, neutrophils are also important in the resolution of inflammation. The failure of neutrophils to migrate can lead to an inability to control infection due to weakened neutrophil phagocytic and bactericidal abilities (2.....
Document: As previously reported, the present study observed that LPS stimulation decreased the expression of CXCR1, CXCR2 and CD62L on neutrophils. In addition to being effector cells involved in the acute phase of the inflammatory response, neutrophils are also important in the resolution of inflammation. The failure of neutrophils to migrate can lead to an inability to control infection due to weakened neutrophil phagocytic and bactericidal abilities (26) . CXCR1 and CXCR2 are the major chemokine receptors on neutrophils. Chemokine receptors regulate the migration of neutrophils to the site of infection to assist in controlling invading pathogens and protecting the body. Duerschmied et al (27) demonstrated that survival following LPS-induced endotoxic shock improved upon the promotion of neutrophil recruitment during acute inflammation. n-butanol extract was found to have significant antiseptic abilities in our previous study. However, whether the extract affected neutrophil migration remained unclear. In the present study, it was demonstrated that n-butanol extract prevented the downregulation of CXCR1, CXCR2 and CD62L.
Search related documents:
Co phrase search for related documents- acute inflammation and effector cell: 1
- acute inflammation and inflammation resolution: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- acute inflammation and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- acute inflammation and LPS stimulation: 1, 2, 3
- acute inflammation and neutrophil failure: 1
- acute inflammation and neutrophil migration: 1
- acute inflammation and neutrophil recruitment: 1, 2, 3, 4, 5
- acute inflammation and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- acute inflammation and previous study: 1, 2, 3
- acute inflammation and previously report: 1
- acute inflammation and unclear remain: 1, 2, 3, 4
- acute phase and chemokine receptor: 1, 2
- acute phase and effector cell: 1, 2, 3, 4, 5, 6
- acute phase and inflammation resolution: 1
- acute phase and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- acute phase and inflammatory response acute phase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- acute phase and neutrophil failure: 1, 2
- acute phase and neutrophil migration: 1
- acute phase and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63
Co phrase search for related documents, hyperlinks ordered by date